Isao Okayasu Selected Research

Adenoma (Adenomas)

5/2011	High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions.
3/2007	Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.
1/2006	Bottom-up cell proliferation with cyclin A and p27Kip1 expression in ulcerative colitis-associated dysplasia.
5/2003	Apoptosis regulation differs between ulcerative colitis-associated and sporadic colonic tumors. Association with survivin and bcl-2.
4/2002	Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase.

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Isao Okayasu Research Topics

Disease

38	Neoplasms (Cancer) 06/2020 - 02/2002
25	Ulcerative Colitis 05/2022 - 08/2002
25	Carcinoma (Carcinomatosis) 02/2018 - 03/2002
15	Adenocarcinoma 10/2014 - 02/2002
10	Carcinogenesis 02/2011 - 04/2002
9	Inflammation (Inflammations) 02/2018 - 07/2003
9	Endometrial Neoplasms (Endometrial Cancer) 02/2011 - 01/2003
7	Colitis 01/2016 - 10/2002
6	Colorectal Neoplasms (Colorectal Cancer) 08/2020 - 05/2007
5	Prostatic Neoplasms (Prostate Cancer) 07/2021 - 07/2005
5	Adenoma (Adenomas) 05/2011 - 04/2002
4	Infections 11/2005 - 01/2003
3	Neoplasm Metastasis (Metastasis) 12/2013 - 07/2006
3	Astrocytoma (Pilocytic Astrocytoma) 01/2010 - 07/2004
3	Glioblastoma (Glioblastoma Multiforme) 01/2010 - 07/2004
3	Stomach Neoplasms (Stomach Cancer) 12/2009 - 08/2006
3	Lung Neoplasms (Lung Cancer) 10/2009 - 02/2004
2	Breast Neoplasms (Breast Cancer) 09/2021 - 01/2018
2	Lymphatic Metastasis 09/2021 - 07/2015
2	Endometrioid Carcinoma 05/2014 - 07/2004
2	Hemangiosarcoma (Angiosarcoma) 12/2013 - 03/2010
2	Papillary Carcinoma 05/2013 - 04/2002
2	Fibrosis (Cirrhosis) 02/2013 - 01/2011
2	Abscess 06/2012 - 05/2009
2	Rectal Neoplasms (Rectal Cancer) 03/2011 - 12/2007
2	Ulcer 12/2010 - 01/2009
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/2010 - 10/2008
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/2010 - 10/2009
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/2009 - 10/2004
2	Diarrhea 12/2007 - 11/2002
2	Mycoses (Diseases, Fungus) 01/2006 - 11/2003
2	Small Cell Carcinoma 10/2004 - 02/2004
1	Triple Negative Breast Neoplasms 09/2021
1	Hypoxia (Hypoxemia) 08/2020
1	Immune System Diseases (Immune Disorders) 01/2018
1	Lung Diseases (Lung Disease) 01/2017
1	Asthma (Bronchial Asthma) 01/2017

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 06/2020 - 03/2002
13	Biomarkers (Surrogate Marker)IBA 06/2020 - 11/2006
10	Amino Acid Transport Systems (Amino Acid Transporter)IBA 09/2021 - 01/2009
8	beta CateninIBA 04/2011 - 01/2003
7	Formaldehyde (Formol)FDA Link 07/2010 - 01/2006
7	ParaffinIBA 07/2010 - 01/2006
6	ProstaglandinsIBA 05/2022 - 07/2014
6	Cyclin D1IBA 03/2010 - 05/2004
5	11 alpha- hydroxy- 9,15- dioxo- 2,3,4,5,20- pentanor- 19- carboxyprostanoic acidIBA 01/2017 - 01/2014
5	Dextran SulfateIBA 01/2016 - 10/2002
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2013 - 07/2004
4	Messenger RNA (mRNA)IBA 03/2011 - 02/2004
4	Cyclin-Dependent Kinase Inhibitor p16IBA 03/2010 - 11/2006
4	Cyclin AIBA 08/2009 - 07/2004
4	DNA (Deoxyribonucleic Acid)IBA 03/2007 - 02/2003
4	EnzymesIBA 11/2006 - 01/2003
3	Progesterone Receptors (Progesterone Receptor)IBA 09/2021 - 01/2003
3	Dinoprostone (PGE2)FDA Link 01/2017 - 07/2014
3	AzoxymethaneIBA 01/2016 - 11/2002
3	Estrogen ReceptorsIBA 05/2014 - 03/2004
3	Estrogens (Estrogen)FDA Link 12/2013 - 11/2007
3	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/2013 - 01/2011
3	Monoclonal AntibodiesIBA 05/2011 - 01/2009
3	Irinotecan (Camptosar)FDA LinkGeneric 03/2011 - 12/2007
3	MucinsIBA 12/2010 - 01/2008
3	Tumor Suppressor Protein p14ARF (p14ARF)IBA 09/2007 - 07/2004
3	Chromogranin AIBA 08/2006 - 02/2004
2	Thymidine KinaseIBA 07/2021 - 11/2006
2	Immunoglobulin A (IgA)IBA 01/2018 - 01/2016
2	AcidsIBA 01/2016 - 03/2006
2	Immunoglobulin G (IgG)IBA 01/2016 - 01/2003
2	Indicators and Reagents (Reagents)IBA 10/2014 - 11/2009
2	CytokinesIBA 06/2012 - 05/2009
2	Hematoxylin (Haematoxylon)IBA 09/2011 - 05/2004
2	Eosine Yellowish-(YS) (Eosin)IBA 09/2011 - 05/2004
2	AntigensIBA 04/2011 - 08/2002
2	Complementary DNA (cDNA)IBA 03/2011 - 11/2007
2	Butyric Acid (Butanoic Acid)IBA 03/2011 - 03/2006
2	SodiumIBA 12/2010 - 11/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2010 - 11/2005
2	NF-kappa B (NF-kB)IBA 01/2010 - 05/2009
2	Transcription Factors (Transcription Factor)IBA 01/2010 - 05/2004
2	Cadherins (E-Cadherin)IBA 06/2009 - 03/2007
2	Cyclin EIBA 01/2006 - 07/2004
2	Coloring Agents (Dyes)IBA 11/2004 - 01/2003
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 07/2004 - 04/2002
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2004 - 04/2002
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 03/2004 - 02/2002
1	human ERBB2 proteinIBA 09/2021
1	Ganciclovir (Cytovene)FDA LinkGeneric 07/2021
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 08/2020
1	ProteomeIBA 02/2018
1	ThioredoxinsIBA 02/2018
1	PeroxiredoxinsIBA 02/2018
1	7- hydroxy- 5,11- dioxotetranorprostane- 1,16- dioic acidIBA 01/2018

Therapy/Procedure

13	Therapeutics 06/2020 - 01/2003
5	Drug Therapy (Chemotherapy) 01/2014 - 11/2003
5	Lasers (Laser) 12/2009 - 10/2003
2	Chemoradiotherapy 03/2011 - 12/2007
2	Adjuvant Chemotherapy 11/2010 - 12/2009
2	Gastrectomy 12/2009 - 02/2002
2	Intraperitoneal Injections 11/2006 - 11/2002
2	Oral Administration 01/2003 - 11/2002